Sexual Health (Men)
Evidence-based approaches to male sexual function
Medical Disclaimer
Compounds studied for erectile function, libido, and overall male sexual health. This area has some of the strongest pharmaceutical evidence in the peptide-adjacent space.
Protocol Map
Compounds organized by evidence tier. Foundation compounds have the strongest clinical support. Emerging compounds show promise but lack robust human data.
Foundation
PDE5 inhibitors for erectile function
PDE5 inhibitors are the first-line treatment for erectile dysfunction with decades of RCT data. Sildenafil (on-demand, 4-6 hour duration) and Tadalafil (daily low-dose or on-demand, up to 36 hours) have different pharmacokinetic profiles suited to different patient needs.
Commonly Added
Address underlying hormonal deficiency
Low testosterone is a common contributor to decreased libido and erectile function. TRT in men with confirmed hypogonadism has been shown to improve desire, arousal, and erectile function in multiple RCTs. Should be confirmed with morning labs.
Central-acting sexual function agent
A melanocortin receptor agonist that acts on the central nervous system rather than the vascular system. FDA-approved for female HSDD; used off-label in men when PDE5 inhibitors are insufficient. Works on desire/arousal pathways.
Emerging
Bonding and arousal support
Sometimes called the "bonding hormone." Small studies suggest nasal oxytocin may enhance sexual satisfaction and partner bonding. Evidence is preliminary, and the clinical significance of effects remains debated.
Recommended Monitoring
Lab work and clinical assessments commonly recommended when pursuing this goal. Your provider will determine the appropriate testing schedule for your situation.
| Test | Frequency | Purpose |
|---|---|---|
| Total and Free Testosterone | Baseline (morning draw), then every 6 months if on TRT | Confirm hypogonadism and monitor replacement therapy |
| Estradiol (sensitive) | Baseline, then every 6 months if on TRT | Estrogen balance affects libido and erectile function |
| Cardiovascular Assessment | Baseline, especially before starting PDE5 inhibitors | ED can be an early marker of cardiovascular disease; screening is essential |
| Prolactin | Baseline | Elevated prolactin is a treatable cause of sexual dysfunction |
| Thyroid Panel | Baseline | Both hypo- and hyperthyroidism can impair sexual function |
| Lipid Panel | Baseline, then annually | Cardiovascular risk assessment; vascular health directly impacts erectile function |
Lifestyle Foundations
Cardiovascular exercise is directly correlated with erectile function -- even moderate walking 30 minutes daily shows measurable improvement in clinical studies. Maintaining a healthy weight reduces estrogen conversion and improves vascular health. Sleep quality impacts testosterone production, which peaks during deep sleep. Stress management and mental health support are critical, as psychological factors are the primary contributor to ED in men under 40. Limiting alcohol to moderate intake preserves both hormonal balance and sexual function.
Related Goals
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The compounds on this page require medical supervision and prescriptions. A qualified provider can evaluate whether these approaches are appropriate for you.
Explore Practical Guides →Important Disclaimer
The information provided on this page is for educational and informational purposes only. It is not intended as, and should not be construed as, medical advice, diagnosis, or treatment. The compounds, dosages, and protocols discussed are summaries of published research and do not constitute prescriptions or treatment plans. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment protocol. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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