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GHK-Cu Dosing Guide

Evidence-based dosing protocols across 2 administration approaches.

Dosing Protocols

Parenteral (Injection)

Off-Label ClinicSubcutaneous

Dose Range

12 mg

Frequency

daily

Duration

Day 1-15: 1 mg/d; Day 16-30: 2 mg/d; then 30 days off

Source

PMC6073405; PMC8789089

No official human dosing guidelines. Protocols based on clinical practice.

Topical (Skin)

Off-Label ClinicTopical

Dose Range

0.55 mg

Frequency

daily

0.5-5% concentration applied 1-2×/d. Double-blind trial: 55.8% wrinkle reduction vs control at 8 wk.

Administration

Delivery methods

Topical creamSubcutaneous injectionMicroneedling

Pending physician review — consult your provider before use.Updated 2026-04-10

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