Emerging ResearchFDA Approved
Methylene Blue Dosing Guide
Evidence-based dosing protocols across 3 administration approaches.
Medical Disclaimer
This dosing information is for educational reference only. Dosing decisions require physician oversight. Do not self-prescribe or adjust dosing without consulting a qualified healthcare provider.
Dosing Protocols
Cognitive Enhancement (Low-Dose)
Off-Label ClinicOralDose Range
0.5–25 mg
Frequency
daily
Source
PMC10631450; PMC5018244
Clinic protocols: 5-25 mg/d, 5 days/wk. Hormetic dose-response: lower may be more effective than higher. Blue urine is harmless.
Alzheimer's Dose-Finding Trial
Clinical TrialOralDose Range
69–228 mg
Frequency
daily
321 AD patients, 24 wk. Three divided doses with food. 228 mg/d: ADAS-cog improvement 5.42 pts better than placebo.
Methemoglobinemia (FDA-Approved)
FDA ApprovedIntravenousDose Range
1–2 mg
Frequency
as needed
Source
Provayblue FDA Label
1-2 mg/kg IV over 5-30 min. Clinical setting only. Dose is per kg body weight.
Administration
Delivery methods
Oral liquidOral capsuleIntravenous
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Pending physician review — consult your provider before use.Updated 2026-04-10