Clinical Data
MK-677 — Interactions & Safety Profile
3 contraindications1 known interaction⚠ Pregnancy warning
Medical Disclaimer
This safety information is for educational purposes only. Drug interactions can vary based on individual factors. Always consult a physician before combining compounds.
Contraindications
Congestive heart failure or risk factors
6.5% CHF rate vs 1.7% placebo in hip fracture trial. Development halted due to cardiac safety signal.
Active cancer
GH/IGF-1 elevation.
Uncontrolled diabetes
MK-677 raises fasting glucose and may worsen glycemic control.
Drug Interactions
Diabetes medicationsModeratemoderate interaction
MK-677 raises blood glucose. May counteract diabetes medications.
Monitor glucose closely; may need to increase diabetes medication.
Monitoring Required
- •Fasting glucose / HbA1c (MK-677 raises blood glucose)
- •IGF-1 levels
- •Cardiac function (CHF signal in clinical trials)
Pregnancy & Nursing
No safety data. Avoid in pregnancy.
⏳
Pending physician review — consult your provider before use.