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TRUTH IN PEPTIDES
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NAD+ Dosing Guide

Evidence-based dosing protocols across 3 administration approaches.

Dosing Protocols

IV Infusion

Off-Label ClinicIntravenous

Dose Range

250750 mg

Frequency

variable

Source

PMC7558103; PMC6751327

Loading: 250-500 mg daily × 3-5 days. Maintenance: monthly. 6-hour infusion typical. Slow rate to reduce flushing/nausea.

Subcutaneous Injection

Off-Label ClinicSubcutaneous

Dose Range

50200 mg

Frequency

weekly

Start 50 mg/wk, increase to 100 mg/wk if tolerated. More practical than IV for home use.

Oral Precursors (NMN)

Off-LabelOral

Dose Range

2501250 mg

Frequency

daily

NMN or NR. Sublingual may improve bioavailability. Up to 1200 mg/d tested without serious AEs.

Administration

Delivery methods

Intravenous infusionSubcutaneous injectionOral supplementNasal spray

Pending physician review — consult your provider before use.Updated 2026-04-10

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