Foundation tier · Cognitive Function
Methylene Blue for Cognitive Function
A synthetic dye with FDA approval for methemoglobinemia, now explored for cognitive and mitochondrial support.
Medical Disclaimer
Why Methylene Blue for Cognitive Function
Role in Protocol
Mitochondrial support and neuroprotection
Evidence Note
At low doses (0.5-4 mg/kg), methylene blue acts as an alternative electron carrier in mitochondria and has shown neuroprotective effects in preclinical models. Human studies in Alzheimer disease and traumatic brain injury are ongoing. Has FDA approval at higher doses for methemoglobinemia.
Dosing Context
Cognitive Enhancement (Low-Dose)
Dose
0.5–25 mg
Frequency
daily
Alzheimer's Dose-Finding Trial
Dose
69–228 mg
Frequency
daily
Key Safety Notes
G6PD deficiency
Risk of severe haemolytic anaemia. Screen all patients before use.
Severe renal insufficiency
Methylene blue is primarily renally excreted.
Known hypersensitivity to methylene blue or phenothiazine compounds
Cross-reactivity with phenothiazine class.
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