Emerging tier · Anti-Aging & Longevity
Methylene Blue for Anti-Aging & Longevity
A synthetic dye with FDA approval for methemoglobinemia, now explored for cognitive and mitochondrial support.
Medical Disclaimer
Why Methylene Blue for Anti-Aging & Longevity
Role in Protocol
Mitochondrial electron carrier
Evidence Note
Acts as an alternative electron carrier in the mitochondrial electron transport chain. Preclinical data show improved mitochondrial function and neuroprotection. Human longevity data are preliminary.
Dosing Context
Cognitive Enhancement (Low-Dose)
Dose
0.5–25 mg
Frequency
daily
Alzheimer's Dose-Finding Trial
Dose
69–228 mg
Frequency
daily
Often Used Alongside
Key Safety Notes
G6PD deficiency
Risk of severe haemolytic anaemia. Screen all patients before use.
Severe renal insufficiency
Methylene blue is primarily renally excreted.
Known hypersensitivity to methylene blue or phenothiazine compounds
Cross-reactivity with phenothiazine class.
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