Emerging tier · Muscle & Performance
MK-677 for Muscle & Performance
Clinical DataResearch Only
An oral growth hormone secretagogue that mimics ghrelin to stimulate GH and IGF-1 release.
Medical Disclaimer
This page is for educational purposes only. It is not a treatment protocol or prescription. All compounds require medical supervision. Consult a qualified healthcare provider before use.
Why MK-677 for Muscle & Performance
Role in Protocol
Oral GH secretagogue
Evidence Note
A non-peptide ghrelin mimetic that elevates GH and IGF-1 levels via oral administration. Human trial data show sustained IGF-1 elevation, though long-term safety data remain limited.
Dosing Context
GH Secretagogue (Oral)
Dose
10–25 mg
Frequency
daily
Often Used Alongside
Key Safety Notes
Congestive heart failure or risk factors
6.5% CHF rate vs 1.7% placebo in hip fracture trial. Development halted due to cardiac safety signal.
Active cancer
GH/IGF-1 elevation.
Uncontrolled diabetes
MK-677 raises fasting glucose and may worsen glycemic control.
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