Peer ReviewedFDA Approved
Rapamycin Dosing Guide
Evidence-based dosing protocols across 2 administration approaches.
Medical Disclaimer
This dosing information is for educational reference only. Dosing decisions require physician oversight. Do not self-prescribe or adjust dosing without consulting a qualified healthcare provider.
Dosing Protocols
Longevity (Intermittent)
Off-LabelOralDose Range
1–6 mg
Frequency
weekly
Source
PEARL Trial; Lancet Healthy Longevity systematic review
Selective mTORC1 inhibition at low/weekly dose. 5 mg/wk most common. Some use biweekly (every 14 d). Start 2-3 mg/wk, increase if tolerated.
Transplant Immunosuppression (FDA-Approved)
FDA ApprovedOralDose Range
2–15 mg
Frequency
daily
Source
Rapamune FDA Label
Escalation Schedule
Loading 6 mg day 1, then 2 mg daily (adjust by trough level)
NOT the longevity protocol. Daily dosing inhibits both mTORC1 and mTORC2. Requires trough monitoring.
Administration
Delivery methods
Oral tabletTopical cream
⏳
Pending physician review — consult your provider before use.Updated 2026-04-10