Rapamycin — Interactions & Safety Profile
Medical Disclaimer
Contraindications
Hypersensitivity to sirolimus or derivatives
Allergic reactions documented.
Active untreated infections
Immunosuppressive at transplant doses; even at low doses, immune function is modulated.
Severe hepatic impairment
Rapamycin is hepatically metabolised via CYP3A4.
Surgery within 2 weeks
Rapamycin impairs wound healing even at low doses.
Drug Interactions
Significantly increase rapamycin blood levels, potentially causing toxicity.
Mechanism: CYP3A4 inhibition reduces rapamycin metabolism.
Avoid grapefruit/grapefruit juice entirely. Monitor levels closely if CYP3A4 inhibitor is necessary.
Dramatically decrease rapamycin levels, rendering it ineffective.
Mechanism: CYP3A4 induction accelerates rapamycin metabolism.
Avoid concurrent use of strong CYP3A4 inducers.
Monitoring Required
- •Lipid panel (rapamycin can elevate triglycerides and cholesterol)
- •CBC with differential
- •Fasting glucose / HbA1c
- •Renal function
- •Liver function
- •Rapamycin trough levels (transplant dosing only)
Pregnancy & Nursing
Contraindicated. Teratogenic potential. Effective contraception required during treatment.
Pending physician review — consult your provider before use.