Peer ReviewedFDA Approved
Tirzepatide Dosing Guide
Evidence-based dosing protocols across 2 administration approaches.
Medical Disclaimer
This dosing information is for educational reference only. Dosing decisions require physician oversight. Do not self-prescribe or adjust dosing without consulting a qualified healthcare provider.
Dosing Protocols
Weight Loss (Zepbound)
FDA ApprovedSubcutaneousDose Range
2.5–15 mg
Frequency
weekly
Source
Zepbound FDA Label; SURMOUNT-1 (NEJM)
Escalation Schedule
Wk 1-4: 2.5 mg → Wk 5-8: 5 mg → increase 2.5 mg every 4 wk → max 15 mg
2.5 mg is initiation only, not a maintenance dose. 91% of patients achieved ≥5% weight loss at 15 mg.
Type 2 Diabetes (Mounjaro)
FDA ApprovedSubcutaneousDose Range
2.5–15 mg
Frequency
weekly
Source
Mounjaro FDA Label
Escalation Schedule
2.5 mg × 4 wk → 5 mg → increase 2.5 mg every 4 wk as needed
Administration
Delivery methods
Subcutaneous injection
⏳
Pending physician review — consult your provider before use.Updated 2026-04-10