Emerging tier · Hormone Optimization (Men)
Enclomiphene for Hormone Optimization (Men)
A selective estrogen receptor modulator used to stimulate endogenous testosterone production.
Medical Disclaimer
Why Enclomiphene for Hormone Optimization (Men)
Role in Protocol
Non-suppressive testosterone elevation
Evidence Note
An alternative to TRT that stimulates endogenous testosterone production via the HPG axis. Phase III data show significant testosterone increases without exogenous suppression. Particularly relevant for younger men and those prioritizing fertility.
Dosing Context
Secondary Hypogonadism
Dose
12.5–25 mg
Frequency
daily
Lower Starting Dose
Dose
6.25–12.5 mg
Frequency
daily
Key Safety Notes
Known hypersensitivity to clomiphene or related compounds
Enclomiphene is the active trans-isomer of clomiphene.
Active thromboembolic disease
SERMs carry thromboembolic risk.
Liver disease
SERMs are hepatically metabolised; impaired clearance in liver disease.
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