Foundation tier · Muscle & Performance
Enclomiphene for Muscle & Performance
A selective estrogen receptor modulator used to stimulate endogenous testosterone production.
Medical Disclaimer
Why Enclomiphene for Muscle & Performance
Role in Protocol
Fertility-preserving alternative to exogenous testosterone
Evidence Note
A selective estrogen receptor modulator that stimulates endogenous testosterone production without suppressing spermatogenesis. Phase III trial data showed significant increases in serum testosterone.
Literature Dosing
12.5-25 mg daily oral
Dosing Context
Secondary Hypogonadism
Dose
12.5–25 mg
Frequency
daily
Lower Starting Dose
Dose
6.25–12.5 mg
Frequency
daily
Often Used Alongside
Key Safety Notes
Known hypersensitivity to clomiphene or related compounds
Enclomiphene is the active trans-isomer of clomiphene.
Active thromboembolic disease
SERMs carry thromboembolic risk.
Liver disease
SERMs are hepatically metabolised; impaired clearance in liver disease.
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